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Comparative Studies | Anaesthesiology | India | Volume 12 Issue 2, February 2023

Comparison of Effect of Preservative Free Ketamine and Magnesium Sulphate used as an Adjuvant to 0.5 % Hyperbaric Bupivacaine in Orthopaedic Lower Limb Surgeries under Spinal Anaesthesia - A Prospective Double Blind Randomised Control Study

Pratheev E ^[3] | Arpita Bhargava ^[3] | Ritushree Sharma ^[3]

Abstract: Background and aim: Spinal anaesthesia is preferred because of its simplicity and reliability in lower limb surgery. It has become a common practice to use adjuvants with local anaesthetics for spinal anaesthesia for treatment of intra and postoperative pain. The aim of the study was to assess the effects of ketamine and magnesium sulphate added to 0.5 % hyperbaric bupivacaine, for spinal anaesthesia in patients undergoing lower limb surgeries. Methodology: This study included 90 patients, who were divided into 3 groups of 30 each. Group Magnesium received 50% magnesium sulphate 50 mg plus 0.5 % hyperbaric bupivacaine 12.5 mg (2.5 ml). Group Ketamine received preservative free ketamine 25 mgplus 0.5 % hyperbaric bupivacaine 12.5 mg. Group Control received plain 0.5% hyperbaric bupivacaine 12.5 mg plus 0.5 ml normal saline. Parameters like sensory and motor block characteristics, visual analog scores (VAS) were recorded. Result: The mean duration of analgesia was 164, 170 and 224 minutes in group C, group K and group M respectively. These differences were statistically significant. Conclusion: This study shows that intrathecal magnesium sulphate, as an adjuvant to 0.5 % hyperbaric bupivacaine prolongs the duration of analgesia, sensory and motor blockade without any major side effects.

Keywords: Ketamine, Magnesium Sulphate, Spinal Anaesthesia

Edition: Volume 12 Issue 2, February 2023,

Pages: 928 - 936