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Research Paper | Pharmacy | India | Volume 12 Issue 12, December 2023
Pharmacological Evaluation of Anti - depressant Activity of Ethanolic Extract of Feronia limonia Leaves in Swiss Albino Mice
Rohit Jatav | Rekha Gour [3] | Anant K. Patel [2]
Abstract: This research was aimed to evaluate the potential anti - depressant activity of Ethanolic Extract of Feronia limonia (EEFL) leaves in Swiss Albino mice. Materials and Methods: Animal group was divided as control (n=2) and received normal saline and negative group (n=3) where no treatment required and six animals were equally divided in standard and low dose of test extract (100mg/kg) and high dose of test extract (200mg/kg). Antidepressant potential of EEFL was evaluated by submitting the mice to Forced Swim Test (FST) and Tail Suspension Test (TST) and Open Field Test. Result: The yield was found to be 29.14% and the EEFL leaves and alkaloids, flavonoids, glycosides, saponins, amino acids, fats, and oils were identified in the extract. The duration of immobility in the FST was reduced in mice treated with the EEFL at 100mg/kg immobility time was 104.3 sec. while at dose 200mg, it was 92.7 sec. this was higher compared to the standard drug fluoxetine (72.9 sec.). In the TST, the immobility time was significantly higher in EEFL at dose 100mg/kg was 104.92 sec. and EEFL at dose 200mg/kg was 94.9 sec. while compared with standard drug fluoxetine at dose 20mg/kg was 84.52 sec. In open field test the EEFL doses of 100 and 200 mg/kg increased peripheral squares crossed by mice but did not significantly increase central square crossings compared to control. Standard drug showed a significant increase in central square crossings. Fluoxetine resulted in a significant increase in animal rearing compared to control. Conclusion: The present study suggested that PF extracts possessed potential antidepressant effects which could be of therapeutic interest for using in the treatment of patients with depressive disorders.
Keywords: Feronia limonia, antidepressant activity, tail suspension test, forced swim test, open field test
Edition: Volume 12 Issue 12, December 2023,
Pages: 1298 - 1301