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Review Papers | Pathology | India | Volume 12 Issue 12, December 2023
Evaluating the Role of Fibrinogen as an Independent Risk Factor in Coronary Heart Disease
Vineetha V. | Dr. Sukesh 
Abstract: The involvement of fibrinogen in the etiology of cardiovascular diseases, such as coronary heart disease, is gaining attention.The significance of plasma fibrinogen as an independent cardiovascular risk factor has come to light in recent years. It is widely established that the majority of cases of unstable angina pectoris, abrupt cardiac ischemia mortality, and acute myocardial infarction (MI) are associated with occlusive thrombi.the primary mechanism underlying these atherosclerotic consequences is thrombosis.An increased risk of stoke and coronary heart disease is linked to an elevated amount of plasma fibrinogen. We address fibrinogen as an independent and changable risk factor for cardiovascular disease, despite its association with other well-known risk factors like age, diet, and smoking. Long-term increases in fibrinogen levels can cause cardiovascular events, particularly atherosclerotic ones. These include fibrinogen infiltration of the vessel wall, increased platelet aggregation and thrombus formation, increased fibrin formation, and effects from increased blood viscosity.It also predicts accelerated coronary atherosclerosis and increases the risk of death or recurrent myocardial ischaemia in patients who have had a prior coronary incident. In fact, research indicates that the positive correlation between elevated levels of plasma fibrinogen and cardiovascular events is as predictive as elevated levels of cholesterol.
Keywords: Fibrinogen, Coronary Heart Disease, Cardiovascular Risk Factors, Atherosclerosis, Thrombosis
Edition: Volume 12 Issue 12, December 2023,
Pages: 65 - 68