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Case Studies | Medicine | India | Volume 13 Issue 1, January 2024

Factors Affecting Management of Acute Ischemic Stroke with Reference to Intravenous Thrombolysis and its Impact on Short Term Outcome

Dr. Juhi Ramnani | Dr. Mudassir Ahmed Abdulgani Ukkund | Dr. Maitreya Kale | Dr. Riya Shah | Dr. Rinal Parikh | Dr. Zalak Gadani ^[2]

Abstract: Background: Stroke is a major global health concern, ranking second in terms of fatality worldwide, following ischemic heart disease. However, few stroke patients arrive at the hospital within the optimal time for thrombolysis, and even among those who do, not all receive this therapy. Therefore, the objective of the study was to examine the factors that influence the treatment of acute ischemic stroke, particularly with intravenous thrombolysis, and to evaluate the short - term outcomes. Methods: This prospective observational study was carried out between August 2019 to August 2021 in the emergency department of tertiary care hospital. Patients with acute ischemic stroke (AIS) who were eligible for intravenous thrombolysis within 4.5 hours of the beginning of symptoms were included in the study. Comprehensive assessments, including history, examinations, and blood investigations, were conducted. Thrombolytic treatment was administered if within the specified time frame, while antiplatelets were given in other cases. Follow - up evaluations were conducted at discharge and 90 days. Results: The age distribution, comorbidities, and CT - MRI findings were similar between individuals who received thrombolysis and those who did not. Among the thrombolysis group, 84% had no complications, while 8% experienced intracerebral hemorrhage, and 8% had an extension of the infarction. The overall mortality rate was 13.33% for non - thrombolysis patients and 12% for thrombolysis recipients, with no statistically significant difference between the two groups. Conclusion: The results highlight the need for careful consideration when deciding to use thrombolysis for AIS cases. Additionally, they emphasize the importance of actively monitoring and effectively managing any potential treatment complications.

Keywords: Stroke, thrombolysis, acute stroke, ischemic stroke, tissue plasminogen activator

Edition: Volume 13 Issue 1, January 2024,

Pages: 310 - 314