Evaluating Serum Lipid Profiles in Postpartum Pituitary Necrosis Sheehan Syndrome Patients: A Comparative Study

Shahnaz Ahmad Mir, Mohmmad Ashraf, Bashrat Dar, Puran Sharma

Abstract: Background: Sheehan's syndrome (SS) refers to the occurrence of varying degrees of hypopituitarism after parturition. Hypopituitary adults with growth hormone deficiency have abnormal body composition with increased fat mass. The present study was undertaken to evaluate the anthropometric, and lipids in SS patients. Material and Method: sixty - three SS patients and forty - four age and BMI - matched controls took part in this study. All patients were stable on conventional replacement therapy for at least one year before the study. The subjects underwent detailed clinical, biochemical and hormone analysis. Results: The SS patients showed significantly higher mean triglyceride, total cholesterol and LDL cholesterol and lower HDL cholesterol concentrations on conventional replacement therapy. This difference was statistically significant with a p value of <0.005. The difference was more marked in obese cases versus obese controls (p= 0.007) than in lean cases and controls. Conclusion: We found significant differences in triglycerides, total cholesterol, LDL, and HDL cholesterol levels. These findings highlight the distinct lipid abnormalities in SS patients, emphasizing the need for targeted management strategies in this patient population.

Keywords: Sheehans Syndrome, Lipid Profile, Hypopituitarism, Postpartum Necrosis, Serum Lipids