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Research Paper | Pharmacology and Toxicology | Volume 12 Issue 10, October 2023 | Pages: 2074 - 2079 | India
Prediction of Rat Oral Toxicity, Genotoxicity and Toxicological Pathways of Selected Phytochemicals of Cannabis sativa Linn.: An in silico Approach
Abstract: It was predicted acute toxicity (rat oral LD50), genotoxicity, toxicological mechanisms of selected phytochemicals of Cannabis sativa. The 11 types of phytochemicals of leaf were selected as per literature.The ProTox-II webserver was used for predictive studies for toxicity and its mechanisms. The rat oral acute toxicity (LD50) as mg/Kg, which predicted as class 4 and 6 toxicity class. Out of 11 compounds, six compounds viz. Delta-9-tetrahydrocannabinol, Cannabidiol, Cannabigerol, Cannabichromene, Oleic acid amide and Cannabidiphorol as Class 4 toxicity [prescribed harmful after swallowing (2000
Keywords: Cannabis sativa, Predictive toxicology, Molecular mechanism of toxicity, Nuclear receptor signalling and stress response pathways
How to Cite?: Kallol Sil, Kaushick Mishra, Soumendra Nath Talapatra, "Prediction of Rat Oral Toxicity, Genotoxicity and Toxicological Pathways of Selected Phytochemicals of Cannabis sativa Linn.: An in silico Approach", Volume 12 Issue 10, October 2023, International Journal of Science and Research (IJSR), Pages: 2074-2079, https://www.ijsr.net/getabstract.php?paperid=SR231028132752, DOI: https://dx.doi.org/10.21275/SR231028132752