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Masters Thesis | Otorhinolaryngology | India | Volume 12 Issue 11, November 2023
Incidence of Anaerobes in Patients with Chronic Rhinosinusitis
Jitendra Gupta | Sachin Jain [6] | Ram Siya Singh | Sankalp Keshari [2] | Pankaj Kumar [35] | Jitendra Chaudhary | Kriti Singh [2]
Abstract: Background: Chronic sinusitis (CS) is an inflammatory disorder of the upper airways, which lasts longer than 12 weeks, often causing residual damage to the sinus mucosa, leading to long-term symptoms. CRS is a multifactorial morbidity, in which the complex microbiome plays a pathogenic role. The present study has been undertaken to determine the incidence of anaerobic microbes in cultures, secretions, and/or mucosal fragments acquired from CRS patients. Materials and Methods: This prospective study was conducted in the Department of ENT & Head Neck Surgery, Moti Lal Nehru, Medical College, and Swaroop Rani Nehru Hospital, Prayagraj from August 2020 to July 2021. The patients of CRS with or without polyp are willing to participate in the study and having age group between 18-45yr irrespective of gender was included in the study. Methods used for obtaining the sample were swabs obtained from middle meatus or ethmoid sinus during FESS or from osteomeatal complex secretions through endoscopy in OPD patients used for quantitative culture sensitivity and identification of organisms. Result and discussion: The mean age of patients was 26.55 ? 7.58 years. Most of the patients fall between the age of 18-24 (51.66%) years. Out of 60 cases, 33(55%) were male and 27(45%) were females. Nasal obstruction was seen in the majority 65% of patients presented with CRS followed by nasal discharge in 18.33%. As per the distribution of microorganisms, aerobes account for (55%), followed by anaerobes (40%), polymicrobial infection (1.67%), and sterile culture were isolated in 2(3.33%) samples. In the present study, we observed that Macrolides (azithromycin), Quinolones (levofloxacin), Cephalosporins (cefuroxime), Penicillin plus ?-lactamase inhibitors (Amoxicillin+clavulanic acid), and Linezolid were quite efficient against the bacteria identified in our investigation. Conclusion: This study was conducted to underline the significance of the identification of specific microorganisms especially anaerobes which seem to be a major cause of chronicity and to assess their susceptibility to specific antimicrobials for targeted therapy and minimization of empirical use of antibiotics.
Keywords: chronic sinusitis, anaerobic bacteria, prospective, microbiology, otolaryngology
Edition: Volume 12 Issue 11, November 2023,
Pages: 676 - 681