Downloads: 5 | Views: 119 | Weekly Hits: ⮙2 | Monthly Hits: ⮙2
Research Paper | Oncology Science | India | Volume 12 Issue 10, October 2023
Epidemiology, Etiology, Clinical Profile and Treatment of Hepatocellular Carcinoma at a Tertiary Care Institute from Tamilnadu Over 5 Year Follow up - A Retrospective Analysis
Dr. Chodavarapu Dheeraj | Dr. K Chandralekha | Dr. Naveen Ravel | Dr. Sathiyamoorthy [2] | Dr. Vijayalakshmi [6] | Dr. Teena Rajan | Dr. K Meena [2]
Abstract: Background: Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy. There is huge caveat in the Indian data on HCC. Aim of this study is to study the prevalence, risk factors, clinical profile and treatment of HCC at a tertiary care institute in Chennai, Tamilnadu. Methods: Data analysis of HCC patients enrolled in a teritary care centre from south India between Jan 2017 and Dec 2021. HCC was diagnosed according to AASLD criteria-Triple phase CT of the abdomen and/or serum alpha-fetoprotein and/or histology (Wherever it is indicated). Barcelona Clinic Liver Cancer (BCLC) staging system was used for staging purposes. Results: We registered 104 HCC patients [males 95 (89%), Females 9 (11%) with mean age 58.3? 11.50 years]. The etiology of HCC was: Ethanol induced 32 (30.8%), Hepatitis B virus 29 (27.9%), Hepatitis C virus 9 (8.7%), NAFLD 13 (12.5%), Idiopathic 21 (20.2%). Serum Alph-fetoprotein was >200 ng/ml in (63.5%) and very high AFP (2000-100000) in 37.5%. Typical radiological features on triple phase CT are seen in 72.1 %, Vascular invasion was seen in 46.2 %, Ruptured HCC are seen in 16.3%and distant metastases in 8%. Loss of weight and appetite (71.2) and Abdominal pain (70.2%)are the most common presenting symptoms. Majority of the patients were BCLC stage C (62.5%) followed by stage B (26%). Biochemical: Thrombocytopenia (47.1%), anaemia in (52.8%) and Altered LFT is observed in 38.4%.99 out of 104 patients were treated of which 80.8% are given Sorafenib, 3.8% underwent TACE and 11.5% underwent hepatectomy.38 patients are alive on treatment 36 patients are dead and 30 patients lost to follow up. Conclusions: In our study we observed that Alcohol is the predominant cause for HCC followed by Hepatitis B. Diagnostic range serum alpha-fetoprotein (>200ng/ml) was detected in 63.5% of study patients. Awareness about alcohol abstinence and good healthy life style practices along with Universal immunization with hepatitis B vaccination may reduce the HBV infection rates and in part HCC burden in near future.
Keywords: Hepatocellular carcinoma, Indian data, epidemiology, risk factors, clinical profile, treatment
Edition: Volume 12 Issue 10, October 2023,
Pages: 498 - 502