Treatment of Pulmonary TB Patients on Antitubercular Medications with Transaminitis

Dr. Putu Dion Pratama Puja

Abstract: Tuberculosis is a disease that caused by Mycobacterium tuberculosis. Tuberculsosis is still a world wide problem. Tuberculosis is the world 13th cause of death. In the 2014 the prevalence of the disease in Indonesia is 254 cases / 100.000. The clinical manifestation of tuberculosis infection in lung are productive cough dan can be accompanied with hemoptoe. Patient can also experience loss of significant body weight, breathless, fatigue, and the symptoms usually worsen at night. Standard treatment of tuberculosis according to World Health Organization are isoniazid, rifampicin, pyrazinamid, etambutol, and streptomycin. The side effect of these drugs are ranged from mild to severe. One of the side effect are transminitis. Monitor the function of liver in the patients that especially have risk factos such as liver disease and other coinfection are recommended. We report a case of transminitis after treatment of antituberculosis drug day 27th. A 59 year old woman complained feeling breathless with pain in epigastric area, nausea, and vomitting. The blood analysis showed increment of SGOT (288 U/L) and SGPT (150 U/L). the antituberculosis treatment was stopped and the patient has received the symptomatic treatment. After 4 days, the patient?s condition got better and the liver function in day 5th was SGOT (35 U/L) normal although there was still elevated level of SGPT (72 U/L).

Keywords: Tuberculosis, Transaminitis, Antituberculosis Treatment