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Case Studies | Dermatology | India | Volume 12 Issue 4, April 2023

Assessment of Efficacy and Safety Profile of Platelet Rich Plasma (PRP) Therapy with Derma Roller in the Treatment of Female Pattern Hair Loss

Jayanthi N S | Anandan V | Prithivirajan B | Deborah Roselin A

Abstract: Background: PRP, known as "Growth Factor Cocktail" is Plasma rich in Growth factors. It is an autologous platelet gel having a large concentration of platelets suspended in a small volume of plasma (1 lakh/?L) above the baseline. This unique power-packed composition of Growth factors contained within alpha granules of platelets act on stem cells in the bulge area of hair follicles to stimulate development of new follicles along with neovascularization. Materials and Methods: After routine investigations and informed consent, 40 female patients with female pattern hair loss were selected. During each sitting, scalp was cleansed, dried and topical anesthetic cream applied. PRP was prepared by double spin method. First centrifugation to separate Plasma and second centrifugation for Platelet concentration. Micro needling with Derma roller was done in affected areas of scalp in a controlled manner in all directions until pin point bleeding is seen. The prepared PRP was applied in those areas of the scalp. Clinical photographs and Grading done before and after procedure for a period of 6 months (4 monthly sittings and 2 months follow-up). Results: Before procedure, according to Sinclair?s scaling, 18.4% of patients had Grade II alopecia (widening of central part) 57.9% had Grade III (widening of central part and thinning on either side), 23.7% had Grade IV (emergence of diffuse hair loss). After procedure, none were in Grade IV, 13.2% had Grade III, 76.3% improved to Grade 2 and 10.5% to Grade I (Normal). 53% patients required 3 sittings to show improvement. Pain (5.3%) was the frequent adverse effect. Conclusion: PRP is a treatment modality that has gained popularity for Alopecia due to its minimal invasiveness, absence of major side effects and more affordable cost compared with hair restoration surgeries. Being an autologous product, the risk of infection and immune rejection is minimized.

Keywords: Centrifugation, Micro needling, Alopecia, minimally invasive

Edition: Volume 12 Issue 4, April 2023,

Pages: 1186 - 1191