Profile of Adenocarcinoma in Cohort of Female Lung Cancer Related Second Hand Smoker
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 2 | Views: 226 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Biomedical Sciences | Indonesia | Volume 12 Issue 2, February 2023 | Popularity: 5.1 / 10


     

Profile of Adenocarcinoma in Cohort of Female Lung Cancer Related Second Hand Smoker

R. A Henny Anggriani, Noni Novisari Soeroso, Setia Putra Tarigan, Putri C Eyanoer, Hidayat


Abstract: Background: Environmental tobacco smoker is the major significant factor in developing lung cancer in females never smokers. There are two products of cigarette smokes; mainstream and side stream smoke that both of these smoke will be metabolyzed by CYP2A6 in both active and passive smoker. Further, adenocarcinoma is the most common histology in lung cancer related to female never smoker and strongly related to nicotine metabolism in the carcinogenesis. Objectives: This study aimed to assess the genetic polymorphism of CYP2A6 and cytology characteristics in female second - hand smokers who suffered from lung cancer among the North Sumatera population. Methods: A cross sectional study was carried out in three centers of cancer hospital in Medan with a total of 53 subjects enrolled in this study from purposive sampling. The diagnosis of lung cancer was confirmed by clinical, radiology, cytology, and histopathology preparation. The CYP2A6 gene was examine by PCR - RFLP from blood. Data were analyzed with the Conditional Logistic Regression test using Epi info 7.0 software. Results: A total 53 subjects diagnosed with lung cancer, with 51 participants had adenocarcinoma type. The most common genotype is wild type, including *1A/*1A (31.3%), *1A/*1B (27.4%), *1B/*1B (39.2%). Meanwhile, only 1 subject had mutant type *4A/*4A (1.9%). For allele, only 1 subject had mutant type *4A (1.9%), while the wild type were counted as *1A (58.8%), *1B (39.2%). There was no significant associations between genotype of CYP2A6 and the incidence of lung adenocarcinoma (p = 0.61). Neither was the alelle of CYP2A6 and the incidence of lung adenocarcinoma (p = 0.25). Conclusion: Adenocarcinoma is the most common histology in female never smoker. Yet, there was just 1 subject had the mutant type of CYP2A6, so this study cannot associate between allele and genotype of lung cancer and the incidence of lung adenocarcinoma.


Keywords: Polymorphism, CYP2A6, Polymerase Chain Reaction - Restriction Fragment Length Polymorphism (PCR - RFLP), Female Second Hand Smokers, Lung Cancer, Cytology of Lung Cancer


Edition: Volume 12 Issue 2, February 2023


Pages: 567 - 569


DOI: https://www.doi.org/10.21275/SR221229085849



Make Sure to Disable the Pop-Up Blocker of Web Browser


Text copied to Clipboard!
R. A Henny Anggriani, Noni Novisari Soeroso, Setia Putra Tarigan, Putri C Eyanoer, Hidayat, "Profile of Adenocarcinoma in Cohort of Female Lung Cancer Related Second Hand Smoker", International Journal of Science and Research (IJSR), Volume 12 Issue 2, February 2023, pp. 567-569, https://www.ijsr.net/getabstract.php?paperid=SR221229085849, DOI: https://www.doi.org/10.21275/SR221229085849

Similar Articles

Downloads: 90

M.Tech / M.E / PhD Thesis, Biomedical Sciences, Indonesia, Volume 9 Issue 6, June 2020

Pages: 1106 - 1108

Major Autohaemotherapy Reduced Free Radical Content and MDA of Heavy Smoker

Henti Widowati, Wimpie Pangkahila, Alex Pangkahila

Share this Article

Downloads: 114

Research Paper, Biomedical Sciences, Egypt, Volume 6 Issue 7, July 2017

Pages: 855 - 860

Vorinostat Combined with DNMTi Epigenetically Controls the Proliferation of Lung Cancer Cells A549

Hussein Sabit, Mostafa Fathy, Shimaa E. Abdel-Ghany, Osama A. M. Said, Mokhtar M. El-Zawahry

Share this Article
Top