International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Case Studies | Dermatology | India | Volume 11 Issue 12, December 2022 | Rating: 4.5 / 10


A Rare Case Report of Non-Familial Acrokeratosis Verruciformis of Hopf

Dr. Shaik Humera | Dr. Deepak Tony Raj


Abstract: Acrokeratosis verruciformis of Hopf is a rare genodermatosis with an autosomal dominant inheritance. It is a disorder of keratinization, characterized by multiple, flat-topped, skin-colored keratotic lesions resembling plane warts typically observed on the dorsum of the hands and feet. Histopathologically, the lesion shows hyperkeratosis, acanthosis, and papillomatosis, mimicking a "church spire", and a thickened granular layer. It arises in early life, often at birth or infancy. Herein, we report on a rare sporadic case of acrokeratosis verruciformis of Hopf. A 50 year old male presented with asymptomatic skin lesions on the extremities which are spreading bilaterally and symmetrically since six years multiple hyper-pigmented, hyperkeratotic discrete papules on the dorsum of hands and feet extending on to lower one third of tibia were present. His past and personal history is not significant. Family history is unremarkable. Histopathological examination showed typical findings of acrokeratosis verruciformis of Hopf. Our case is unique in that the patient had no familial history of similar skin lesions.


Keywords: Genodermatosis, Acrokeratosis verruciformis of Hopf, Non-familial acrokeratosis verruciformis ,keratotic lesions, Church spire


Edition: Volume 11 Issue 12, December 2022,


Pages: 768 - 769


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