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Research Paper | Medical Science | India | Volume 11 Issue 12, December 2022
Diastolic Dysfunction in Asymptomatic Type 2 Diabetes Mellitus with Normal Systolic Function
Abstract: Background: The incidence of heart failure in diabetic subjects is high even in the absence of hypertension and coronary artery disease. Aims: The purpose of this study was to study the incidence of diastolic dysfunction in diabetic subjects and its relation to age, duration of diabetes mellitus (DM), Glycosylated hemoglobin (HbA1c) levels, obesity indices and diabetic microangiopathies. Settings and Design: This was a case control prospective study conducted at the teaching hospital during a one year period. Materials and Methods: A total of 75 subjects (case) with type 2 diabetes of more than five years duration were studied. Total 75 healthy subjects were included as the control group. Echocardiography was performed to assess left ventricular diastolic function. Results: Out of the total 75 subjects, 43 (57%) from the case group had diastolic dysfunction, and 11% amongst 75 in the control group population showed the diastolic dysfunction (P < 0.001). Patients with a longer duration of DM (of 16 to 20 years) had a higher prevalence of diastolic dysfunction (P < 0.02). Subjects with high BMI had statistically significant diastolic dysfunction with ?P? =0.001 and ?P? = < 0.02 respectively. Subjects with HbA1c > 7.5% had a higher prevalence of diastolic dysfunction than subjects with HbA1c < 7.5% (P < 0.02). Conclusions: Present study reveals high incidence of diastolic dysfunction in asymptomatic diabetic; subjects and, this finding was correlated with the duration of diabetes, HbA1c levels, obesity indices. We conclude that early diagnosis and institution of treatment will reduce morbidity and improve the outcomes, and prevent future heart failure.
Keywords: Diastolic dysfunction, diabetes mellitus, echocardiography, heart failure
Edition: Volume 11 Issue 12, December 2022,
Pages: 591 - 597