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Research Paper | Medical Science | Albania | Volume 11 Issue 11, November 2022
Histologic Pattern of Intracranial Tumors in Children
Arben Preza [2] | Alketa Hoxha [6]
Abstract: The objective of present study was to observe the histopatological pattern of intracranial tumors in children (<15 yrs) and to correlate the site of lesion along with the histological diagnosis. Setting: This is a retrospective study conducted at University Hospital Centre ?Mother Teresa? in Tirana, Albania during 2015-2019 including 54 children 3 to 14 years old diagnosed with brain tumous. The initial histological evaluation of these lesions was performed on H and Estained section of paraffin embedded tissue. Special stains and immunhistochemical analysis was done whenever indicated. During the study period, fifty-four cases of intracranial tumors were diagnosed in children. The age ranged from 1-1/2 years to 4 years with male to female ratio of 1.1:1. Astrocytoma comprised 39% of all intracranial tumors of childhood. Medulloblastoma (18.6%) ranked the second most prevalent brain tumor followed by empendymoma (13%), oligodendroglioma 7.5% while nonHodgkn?s lymphoma, primitive neuroblastoma 3.7% and ganlioglioma 3.7% while non-Hodgkin?s lymphoma, primitive neuroectodermal tumors, mixed germ cell tumor, pineoblastoma, choroid plexus carcinoma and malignant meningioma constituted 1.8% each. Astrocytoma was the most common pediatric brain tumor. Medulloblastoma was more common in males while pilocytic astrocytoma was more frequent in females. Posterior cranial fossa was the most common site (43.5%) of pediatric brain tumors. Low grade astrocytoma was more prevalent in posterior cranial fossa as compared to high grade astrocytoma which was more frequent in the supratentorial region.
Keywords: pediatric brain tumours, intracranial, morphology, histologic pattern
Edition: Volume 11 Issue 11, November 2022,
Pages: 687 - 689