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Comparative Studies | Anaesthesiology | India | Volume 11 Issue 11, November 2022 | Popularity: 4.7 / 10
Dexmedetomidine as an Adjuvant to Levobupivacaine in Paravertebral Block for Postoperative Analgesia after Breast Cancer Surgery
Dr. Mudhanuru Bhargava Mallesh Yadav, Dr. G. Vijaya Lakshmi, Dr. Anil Kumari, Dr. Joga Aparna
Abstract: Introduction: Currently regional technique-thoracic paravertebral block for postoperative analgesia after breast surgery is gaining popularity. Aim of the study is to find out the safety and the analgesic efficacy of 1 ?g/kg dexmedetomidine when added to levobupivacaine 0.25% in paravertebral blocks (PVB) in patients undergoing breast cancer surgery. Methods: Sixty American Society of Anaesthesiologists physical statusI/II patients posted for breast cancer surgery were randomly assigned into two groups of 30 each. Group L received thoracic PVB with 20 mL of levobupivacaine 0.25%. Group LD received thoracic PVB with 20 mL of levobupivacaine 0.25% + 1 ?g/kg dexmedetomidine. Time of first analgesics request, total analgesic consumption, VAS score, hemodynamic, sedation score and side effects in the first 24 hours were recorded. Results: The time of the first rescue analgesic requirement was significantly prolonged in the group LD (8.15 ? 2.21 hours) in comparison to group L (6.34 ? 2.83 hours). The mean total consumption of intravenous tramadol as rescue analgesia in the post-anaesthesia care unit in the first 24 hours postoperatively was significantly decreased in group Levobupivacaine + Dexmeditomidine compared to group Levobupivacaine. Conclusion: The addition of dexmedetomidine 1 ?g/kg to levobupivacaine 0.25% in PVB in patients undergoing breast cancer surgery improves the quality and the duration of analgesia postoperatively.
Keywords: Dexmedetomidine, Levobupivacaine, Paravertebral Block, Postoperative Analgesia, Breast Cancer
Edition: Volume 11 Issue 11, November 2022
Pages: 414 - 416