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Research Paper | Nursing | India | Volume 11 Issue 1, January 2022

A Study to Assess the Effectiveness of Planned Teaching Programme on Knowledge Regarding Management of Patients with Organophosphorus Poisioning among B.Sc Nursing 4th Year Students of Murari Lal Memorial School and College of Nursing Solan (H.P)

Abhilasha Sharma | Raghunandan Singh

Abstract: Organophosphate poisoning results from exposure to organophosphates (OPs), which cause the inhibition of AChE is critical for nerve function, so the irreversible blockage of this enzyme, which causes acetylcholine accumulation, results in muscle overstimulation. This causes disturbances across the cholinergic synapses and can only be reactivated very slowly, if at all. Paraoxonase (PON1) is a key enzyme involved in OP pesticides and has been found to be critical in determining an organism?s sensitivity to OP exposure. Consumption of OP poison causes many physiological changes which includes, Mydriasis, Bronchodilatation, urinary retention and hypoglycemia. Other symptoms include, tachycardia, hypertension, bradycardia, AV block, bronchospasm, respiratory muscle weakness, as primary symptoms and bronchorrhoea, aspiration pneumonitis, initial fasciculation, paralysis of respiratory muscles, CNS depression, agitation and delirium as secondary symptoms. Initial assessment of patient who consumed OP poisoning includes checking ABC. Lavage is considered in a highly toxic pesticide poisoning case that arrives at hospital within 1-2 hrs. Naso Gastric tube (NG tube) is passed to decompress the stomach and to suck out its content. After aspirating the stomach content, water or normal saline is given in lots through NG tube. Patient?s airway is ensured, and oxygen is provided, lateral position is maintained and patient is observed for convulsions. Atropine is administered, mean while an intravenous infusion is started with normal saline. Pupils are observed for dilatation and lungs for crepitations. If the patient is unconscious he/she is intubated with an endotracheal tube to minimize the risk of aspiration and to facilitate respiratory care.

Keywords: Organophosphorus poisoning, Atropine, Acetylcholine

Edition: Volume 11 Issue 1, January 2022,

Pages: 1184 - 1190