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Experimental Result Paper | Pharmaceutical Science | Indonesia | Volume 11 Issue 11, November 2022
Capacity and Activity Test of Mice Peritoneal Macrophagy Phagocytic from Polyherbal Formula X IN VIVO
Lusi Nursilawati Syamsi | Letitia Desiree | Syamsudin [8] | Bambang Pontjo Priosoeryanto
Abstract: In the human body there are many systems, one of which is the immune system. Compounds that can improve the immune system are called immunomodulators and can be found in plants and animals, including polyherbal X which contains extracts of snakehead fish, curcuma xanthorriza, and moringa. This experimental study aimed to observe the potential of Polyherbal X in increasing the phagocytic capacity and activity of macrophages in DDY male mice in vivo. Mice were divided into 5 groups with two control groups and three test groups, all of which were given non-A Staphylococcus aureus induction on the eighth day after administration of the test drug. The first control group (I) was given aquadest, while the second control group (II) was given a syrup supplement containing 254 mg/kg BWE. Purpurea L. Moench extract. The third group (III) was given polyherbal X 2.176 mg/kgBW, the fourth group (IV) was given polyherbal X 4.352 mg/kgBW, and the fifth group (V) was given polyherbal X 8.705 mg/kgBW orally administered for 7 consecutive days. After the induction on the eighth day, surgery was performed to take the peritoneal fluid of the mice and make a smear. The phagocytic capacity and activity were observed and counted from the smear. The results showed an increase in the capacity and phagocytic activity of macrophages from the test group as evidenced by ANOVA analysis compared with the control group, obtained a Sig value of 0.000 (P<0.05). The conclusion from this study was that the group that had the highest effectiveness in increasing the average data of phagocytic capacity and activity of macrophages was the group that received polyherbal X at a dose of 8.705 mg/kgBW with a capacity of 18,31 and an activity of 79,67% when compared to other groups.
Keywords: Polyherbal X, snakehead fish, Channa striata, curcuma, Curcuma xanthorrhizae Roxb, moringa, Moringa oleifera Lam, phagocytic capacity, activity, Staphylococcus aureus
Edition: Volume 11 Issue 11, November 2022,
Pages: 306 - 309