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Research Paper | Medicine | Indonesia | Volume 11 Issue 11, November 2022
Interleukin-6 and Ferritine Levels as Predictors of Severity of Covid-19 Patients Treated in Adam Malik General Hospital
Sri Mulyaningsih | Parluhutan Siagian | Nelly Efrida Samosir
Abstract: Background: COVID-19 is a new type of disease that has never been previously identified in humans. The virus that causes COVID-19 is called Sars-CoV-2. Cytokine Release Syndrome or cytokine storm as the underlying pathological development of severe COVID-19 disease. Circulating levels of IL-6 are closely related to the severity of COVID-19 infection. Ferritin is a key mediator of immune dysregulation in COVID-19 patients through its immune-suppressing effects and production of pro-inflammatory cytokines that directly contribute to cytokine storm. Methods: This research is an observational study with cross sectional design. This study took blood samples from COVID-19 patients who were treated at RSUP.H. Adam Malik, Medan, research subjects there are 34 patients. Samples were checked for IL-6 and Ferritin. The research was conducted after obtaining ethical approval and informed consent. Result and Discussion: There were 22 male subjects (64.7%) with an average age of 55 years, with the youngest 31 years old and the oldest 73 years old. 23 patients (67.6%) were severe and 11 patients (32.4%) were moderate. Using a ventilator there were 19 patients (55.9%), 17 patients died (50%). Ferritin levels showed a median of 1245.65 ng/mL with the lowest value of 154.69 ng/mL and the highest level of 2000 ng/mL. The median level of IL-6 was 31.35 pg/mL with the lowest level of 1.5 pg/mL and the highest level of 614.20 pg/mL. The Mann Whitney test showed that there was no significant relationship between IL-6 and the severity of COVID-19 (p = 0.204). The Mann Whitney test showed that there was a significant relationship between ferritin and the severity of COVID-19 (p = 0.002). Conclusion: There is no significant relationship between IL-6 and the severity of COVID-19. There is a significant relationship between ferritin and the severity of COVID-19.
Keywords: COVID-19, IL-6, Ferritin
Edition: Volume 11 Issue 11, November 2022,
Pages: 1214 - 1217