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Case Studies | Medical Science | Indonesia | Volume 11 Issue 10, October 2022

Association of the Neutrophil-Lymphocyte Ratio with Lung Function in Patients with Chronic Obstructive Pulmonary Disease at RSUD Sanjiwani Gianyar 2022

Ni Putu Intan Hapsari | Putu Dyah Widyaningsih

Abstract: Background: Chronic Obstructive Pulmonary Disease is characterized by persistent airway obstruction accompanied by a chronic inflammatory response. Neutrophil-lymphocyte ratio widely used to explain inflammatory processes in many diseases. This study aims to evaluate the association between NLR and lung function. Methods: This study is a cross-sectional study with 42 samples of COPD patients who visited the pulmonary department of Sanjiwani hospital between February 2022 - May 2022. The value of NLR is calculated based on the ratio of the absolute value of neutrophils and lymphocytes from the results of routine blood tests. Lung Function test by measuring forced expiratory volume in 1 second (FEV1), Forced vital capacity (FVC), and FEV1/FVC with spirometry. All the data is analyzed with Spearman?s Correlation test and Independent T-Test. Results: Based on a total of 42 patients, most are male (57.1%) and 42.9% female. The highest age range at 60-69 years and >70 years, 40.5% in each group. Spearman correlation showed a positive correlation between NLR and COPD group (r= 0.369, p= 0.016). The Independent T-test showed a significant difference in lung function in patients with low NLR (<3.00) and high NLR (3.00) with a difference in FEV1 0.6043 mL (p= 0.000). Conclusions: NLR can be used as a simple hematological marker in determining the inflammatory process in the course of COPD patients.

Keywords: Neutrophil-lymphocyte ratio, Chronic Obstructive Pulmonary Disease, Lung Function, Forced expiratory volume in 1 second, Forced vital capacity, FEV1, FVC

Edition: Volume 11 Issue 10, October 2022,

Pages: 252 - 255