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Dissertation Chapters | Medical Science | India | Volume 11 Issue 10, October 2022
An Observational Study on Clinical and Biochemical Profile of Patients with Connective Tissue Diseases
Dr. Manoj P. | Dr. Jalpa Kalsariya | Dr. Nirali Dave
Abstract: Background: Connective tissue disorders (CTD) occur in 3?5% of the population. The advent of antibodies to extractable nuclear antigens (ENA) has become a reliable predictor to establish the diagnosis of CTD, sub classify patients into prognostic groups, and monitor disease activity. It is very vital to study the different presenting symptoms and signs of the above as well as the varied systemic involvement since early detection may slow down the progression of the disease. Aims and objectives: 1) To assess proportions of various connective tissue disorders. 2) Different presenting symptoms and signs of connective tissue disorders. 3) Different features of systemic involvement of connective tissue disorders. 4) Different biomarkers of connective tissue disorders. Material and method: A descriptive cross sectional study which included 50 patients based on inclusion and exclusion criteria was conducted in Sir T General Hospital, Bhavnagar, over a period from January 2021 to August 2021. Results and conclusions: The major manifestations in this study, were joint pain (50%), raised skin lesion (46%), itching (44%), discoloration of skin (40%), photosensitivity (34%) and Raynaud phenomenon (26%). SLE was the most common CTD accounting for (42%), followed by scleroderma (26%), MCTD (10%), rheumatoid arthritis (8%) and sjogren syndrome (6%). In this study, Gastrointestinal manifestations (48%) were the most common followed by musculoskeletal manifestation (44%), respiratory (38%), renal (26%), CVS (12%) and CNS (10%) manifestations. Most common positive antibody in SLE was ds-DNA, in scleroderma it wasanti-centromere antibody while all patients of MCTD were positive to U1 RNP, in Sjogren syndrome SS-A was the most common antibody. In the present study based on ANA pattern homogenous pattern was the most common seen in (30%) followed by membranous and nucleolar pattern with (26%) in each. Membranous pattern was the most common pattern in SLE (47.6%), Nucleolar pattern was the most common pattern in scleroderma (53.84%). Homogenous and nucleolar pattern were the most common ones in MCTD with (50%) each. Homogenous pattern was the most common one in RA (100%), and fine speckled was the most common one in Sjogrens (66.66%). Conclusions: Young females were most commonly affected. Cutaneous manifestations of CTD can be an early predictor in giving a clue to impending systemic manifestations. ANA profile predicts systemic involvement, thus helping in the multidisciplinary management.
Keywords: Connective tissue disorders, cutaneous manifestations, systemic manifestations, ANA
Edition: Volume 11 Issue 10, October 2022,
Pages: 229 - 234