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Research Paper | Medicine | Uzbekistan | Volume 10 Issue 9, September 2021
Role of Genetic Markers of Disorder Plate Line of Hemostasis (ITGB3 and ITGA2) in Pathogenesis Ischemic Stroke
Musashaikhov Umidzhon Khusanovich | Musashaikhova Shakhnoza Mamirbekovna | Karimov Hamid Yakubovich Boboev Kodirjon Tukhtabaevich
Abstract: In the course of the study, in 35 patients with ischemic stroke, the associative relationship of the Leu33Pro polymorphism in the integrin beta3 gene (ITGB3) and the polymorphic marker C807T in the integrin alpha-2 gene (ITGA2) in the formation of IS was analyzed. During the study in patients with IS, a significant relationship was established between the risk of developing this pathology and the distribution of predisposing / protective variants of the ITGB3 and ITGA2 polymorphism genotypes. In the studied groups, the actual distribution of genotypes polymorphism Leu33Pro in the gene for integrin beta-3 (ITGB3) and C807T in the gene for integrin alpha-2 (ITGA2) corresponded to those expected at Hardy-Weinberg equilibrium (RHB) (p <0.05).
Keywords: ischemic stroke, Leu33Pro ITGB3 genetic polymorphism, C807T marker in the integrin alpha-2 gene (ITGA2).
Edition: Volume 10 Issue 9, September 2021,
Pages: 690 - 692