International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Case Studies | Medical Science | India | Volume 10 Issue 6, June 2021


Isolated Protein S Deficiency Leading to Cerebral Venous Sinus Thrombophlebitis in Young Male

Dr. Rahul Vemula | Dr. Sunil Kumar [20] | Dr. Charles Abraham | Dr. Anil Magham


Abstract: Protein S is a potent anticoagulant that downregulates thrombin formation and is a vitamin K-dependent glycoprotein which is primarily synthesized in the liver. A deficiency in this protein or decreased activity, as seen in hereditary protein S deficiency, can lead to life-threatening thrombosis. Hereditary protein S deficiency is a rare disease as listed by the National Organization for Rare Disorders (NORD). Dural venous sinus thrombosis is a rare consequence of protein S deficiency and is associated with a risk of increased morbidity and mortality.It is also known to cause venous as well as arterial thromboembolic events commonly occurring in the deep leg and pelvic veins. We are reporting a case of 17 years old male without any risk factors and comorbidities presented with headache, giddiness and diplopia who has been diagnosed with cerebral venous sinus thrombosis and associated protein s deficiency.


Keywords: proteins, cerebral venous sinus thrombosis


Edition: Volume 10 Issue 6, June 2021,


Pages: 1264 - 1266


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