Comparative Observational Study of Low Doseintravaginal Misoprostol Tablet Versus Intracervical Dinoprostone Gel for Induction of Labor

Punam Jain, Indrani Roy, Neelotparna Saikia

Abstract: Aim: To compare the efficacy and safety of low dose vaginal Misoprostol (25 mcg) and intracervical Dinoprostone gel for induction of labor. Method: An observational study was carried out wherein subjects in group 1 received intracervical Dinoprostone gel(0.5mg) and the subjects in group 2received tab Misoprostol 25 mcg per vaginally, 6 hourly for maximum 3 doses (n=48 in each group). Result: The primary outcome, i.e. number of vaginal deliveries within 12 hours of 1st dose of inducing agent was higher in Misoprostol group (31.8 % in group 1 vs 50 % in group 2, p=0.07) The mean IAL interval was shorter in Misoprostol group (9.88 hours in group 1 vs 6.8 in group 2, p=0.6). Statistically significant shorter duration of oxytocin use in Misoprostol group (7.85 hours in group 1 vs 5.16 hours in group 2, p=0.013). There was no significant difference between the mean IDI (14.53 hours in group 1 vs 17.01 hours in group 2, p=0.2) and the maternal and neonatal outcomes of the 2 groups. Conclusion: Low dose (25 mcg) intravaginal Misoprostol appears to be a safe, effective and an economical alternative drug to routinely used Dinoprostone gel for induction of labor, especially in developing countries with low resource settings.

Keywords: low dose, Misoprostol, Dinoprostone, Induction of labor

How to Cite?: Punam Jain, Indrani Roy, Neelotparna Saikia, "Comparative Observational Study of Low Doseintravaginal Misoprostol Tablet Versus Intracervical Dinoprostone Gel for Induction of Labor", Volume 10 Issue 5, May 2021, International Journal of Science and Research (IJSR), Pages: 783-786, https://www.ijsr.net/getabstract.php?paperid=SR21516225821, DOI: https://dx.doi.org/10.21275/SR21516225821