International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Neuroscience | China | Volume 10 Issue 4, April 2021


Cuprizon - Induced MS Mouse Model of Breviscapine: The Role and Mechanism of the Study

Zou Yuan | Zheng Chin-Ri | Xu Junming


Abstract: Multiple sclerosis (Multiple sclerosis, MS) is a progressive, autoimmune disease of the human central nervous system (Central Nervous System, CNS) with myelin loss as the main pathological change. It is characterized by immune cell infiltration, myelin and oligodendrocyte loss and axonal injury. Studies have found that oligodendrocyte progenitor cell maturation disorder may be the main cause of myelin regeneration failure in animal models of multiple sclerosis, neural precursor cell transplantation can improve animal behavior defects by promoting myelin regeneration. Transplantation of neural stem cells (Neural Stem Cells, NSCs) for the treatment of neurological diseases has advantages that are not available by conventional treatment methods such as drugs and surgery. Hence, how to promote endogenous myelin regeneration is one of the main directions of MS research.


Keywords: multiple sclerosis, breviscapine, neural stem cells


Edition: Volume 10 Issue 4, April 2021,


Pages: 1224 - 1227


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