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Research Paper | Neuroscience | China | Volume 10 Issue 4, April 2021

Cuprizon - Induced MS Mouse Model of Breviscapine: The Role and Mechanism of the Study

Zou Yuan | Zheng Chin-Ri | Xu Junming

Abstract: Multiple sclerosis (Multiple sclerosis, MS) is a progressive, autoimmune disease of the human central nervous system (Central Nervous System, CNS) with myelin loss as the main pathological change. It is characterized by immune cell infiltration, myelin and oligodendrocyte loss and axonal injury. Studies have found that oligodendrocyte progenitor cell maturation disorder may be the main cause of myelin regeneration failure in animal models of multiple sclerosis, neural precursor cell transplantation can improve animal behavior defects by promoting myelin regeneration. Transplantation of neural stem cells (Neural Stem Cells, NSCs) for the treatment of neurological diseases has advantages that are not available by conventional treatment methods such as drugs and surgery. Hence, how to promote endogenous myelin regeneration is one of the main directions of MS research.

Keywords: multiple sclerosis, breviscapine, neural stem cells

Edition: Volume 10 Issue 4, April 2021,

Pages: 1224 - 1227