Intermittent Fasting with Moderate-Intensity Physical Exercise Increased Melatonin but Did Not Reduce Body Mass Index in Obese Rats
Abstract: Background: Intermittent Fasting (IF) is a dietarymethod studied to positively affect circadian rhythm and metabolism by increasing melatonin hormone that may promote weight loss in obese individuals. Objective: This study aimed to measure IF with moderate-intensity exercise on increasing melatonin levels and reduce Body Mass Index (BMI). Methodology: An experimental study with pre and post-test control group design was conducted on 36 obese male Wistar rats aged 4-5 months. The subjects weredivided randomly into two groups, the study and control groups, with 18 subjects in each group. The study group underwent IF for 12 hours with moderate-intensity physical exercise, while the control group was given a standard diet with moderate-intensity physical exercise. After four weeks of intervention, melatonin levels assessedusing ELISA (enzyme-linked immunosorbent assay) ; meanwhile, BMI was measured before and after treatment. The comparative test was conducted to compare the results between groups. Results: The results showed that the mean pretest and post-test melatonin levels in the study group increased significantly (0.3530.01vs.0.4790.01; p
Keywords: Intermittent fasting, Obesity, Melatonin, Body mass index, Metabolism, Moderate physical activity
How to Cite?: Novana O. Mantiri, Wimpie Pangkahila, Alex Pangkahila, "Intermittent Fasting with Moderate-Intensity Physical Exercise Increased Melatonin but Did Not Reduce Body Mass Index in Obese Rats", Volume 10 Issue 1, January 2021, International Journal of Science and Research (IJSR), Pages: 786-789, https://www.ijsr.net/getabstract.php?paperid=SR21112182656, DOI: https://dx.doi.org/10.21275/SR21112182656