Formulation and Evaluation of Flurbiprofen Emulgel by Using Natural Permeation Enhancers

Priyanka D. Manmode | Navnath A. Gaikawad | Ankita A. Giramkar | Bharati R. Hole | Dr. Deepak G. Umalkar

Abstract: Flurbiprofen is more active antiinflammtory agent than other NSAIDs product and is usually well tolerated. Emulgel have more absorption power than any other topical formulation like cream, ointment etc. Enhance permeation of flurbiprofen by using natural permeation enhancers and also study physibility of emulgel by using natural permeation enhancers like, Terpenes- Menthol, Camphor, Essential oil- Basil oil, Neem oil, Eucalyptus oil. Emulgel were evaluated for drug content, viscosity, and In-vitro release through the Franz diffusion cell apparatus. The physical stability were check by using stability chamber. Analytical parameter were determine by I. R, SEM, DSC, and Dissolution. Flurbiprofen is highly permeable with Basil oil as a permeation enhance.

Keywords: Flurbiprofen, Basil oil, Permeation Enhancer, Topical drug delivery, Franz diffusion

Edition: Volume 10 Issue 1, January 2021,

Pages: 827 - 832