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Case Studies | Paediatrics | Indonesia | Volume 10 Issue 10, October 2021

Cholestasis with Congenital Heart Disease in Neonates: A Case Report

Cokorda Gede Bagus Pradnyana Sanjaya ^[2] | Romy Windiyanto ^[2]

Abstract: Introduction: Cholestasis in neonates is an obstruction to the flow of bile and substances that must be excreted by the liver, which causes an increase in direct bilirubin and a build - up of bile salts. While congenital heart disease (CHD) is an abnormality in the structure and function of the heart that has been present since birth. The association between neonatal cholestasis and CHD, a finding for this diagnosis has not been investigated previously. Case: We report a case of cholestasis with congenital heart disease type patent ductus arteriosus and atrial septal defect in neonates. Conclusion: Cholestasis in this case was caused by late - onset sepsis and CHD causing systemic disorders, then cholestasis that occurred in the patient was an intrahepatal process. Finally, the theory that liver disease is the result of CHD is more common than heart disease related to liver disease is true.

Keywords: Neonatal Cholestasis, Congenital Heart Disease

Edition: Volume 10 Issue 10, October 2021,

Pages: 281 - 283