Nifedipineversus Isoxsuprine for Suppression of Preterm Labour - A Comparative Randomised Study

Prashant Pawar, Amol Pawar

Abstract: Preterm labour is one of the major causes of infant morbidity and mortality. This study was undertaken to compare the efficacy of Nifedipine and Isoxsuprine for suppression of preterm labour. Objectives - To compare the efficacy of Nifedipine and Isoxsuprine with respect to Days of gestation gained by tocolysis Adverse effects Neonatal outcome. Method - After fulfilling Inclusion & Exclusion criteria a total of 100 patients were included in the study. History regarding age, parity, obstetric history and Gynecological history, general physical and systemic examination was done. Patients were randomized into two groups and were either administered Nifedipine or Isoxsuprine. Statistical analysis was done using Chi-square test. Results - Tocolysis was successful in 45 (90 %) of patients with Nifedipinecompared to 34 (68 %) in Isoxsuprine group (P= 0.0245). The prolongation of pregnancy up to 37 weeks was 23 (46 %) and 13 (26 %) in Nifedipine and Isoxsuprine group respectively.19 (38 %) patients in Nifedipine group had side effects as compared to 42 (84 %) in Isoxsuprine group. Neonatal outcomes were comparable in both the groups.

Keywords: Preterm labour, Isoxsuprine, Nifedipine, Tocolysis, Pregnancy