Laboratory Evaluation of Hypercoaguable State in Myocardial Infarction

Amit Agrawal, Nandu Pande, Balwant Kowe

Abstract: Myocardial infarction is the most important form of ischaemic heart disease and alone is the leading cause of death. Hypercoagulability is well established risk factor for thrombosis that occur in MI. Hypercoagulability is the condition in which coagulation system is out of balance and prone to thrombus formation. Such hypercoagulable state is due to increased levels of coagulation factors or reduced fibrinolytic action. In present study the subjects were divided into 3 groups. Group A - 26 healthy controls, Group B- 22 patients of Acute MI and Group C- 52 patients of Old MI. The battery of test selected were Bledding time, Prothrombin time test, Partial thromboplastin time with Kaolin, and Quantitative determination of fibrinogen in plasma. Present study concludes coagulation parameters especially fibrinogen and PTTK have predictive value in detecting hypercoagulable state in patients of MI, at the same time BT and PT has not shown predictive changes. Thus patients of acute and old MI who are in state of hypercoagulability need preventive measures and appropriate treatment for reduction in mortality and morbidity from such a disastrous disease.

Keywords: Myocardial infarction, Bleeding time, Prothrombin Time, Partial thromboplastin time with Kaolin, Cardiovascular disease