Downloads: 88 | Views: 254
Research Paper | Biomedical Sciences | Iraq | Volume 9 Issue 7, July 2020 | Popularity: 6.8 / 10
Association of Vitamin D Receptor-FOKI Gene Polymorphism with Breast Cancer Risk in Iraqi Female Patients
Anwar M. Al-Janabi, Abdul Hussein A. Algenabi, Salih M. Alkhafaji
Abstract: Background: Breast cancer is the most frequent cancer among women worldwide. In Iraq, it is accounting about one third of the registered women cancers. Different studies have shown that the gene polymorphism in vitamin D receptor (VDR-FOKI) was associated with the susceptibility and pathogenesis of breast cancer. Objective: The study aimed to examine the genotyping utility of Vitamin D receptor (VDR-FokI) gene polymorphism as predictor for the occurrence and progression of breast cancer in Iraqi women. Materials and Methods: This case control study was comprised of two groups, the first group consisted of 300 women histopathologically diagnosed with breast cancer either familial or sporadic with age 22-77 year, the second group included 200 healthy women with age 22-78 year, DNA was extracted from blood and genotyping analysis was carried out by PCR-RFLP. Results: The genotypic analysis revealed that allele frequency of TT genotype (29 %), TC genotype (48 %), and CC genotype (23 %) in breast cancer group, while 64.5 %, 30.5 % and 5 % in the control group respectively. The risk of breast cancer was significantly increased with VDR-FOKI SNP by about three and five folds in heterozygous and homozygous of mutant allele genotypes in patients (OR=3.25, 95 % C. I= 2.16-4.89, P=0.0001 and OR= 5.00, 95 % C. I= 2.81-8.92, P= 0.0001 respectively) when compared with the homozygous of normal alleles genotype after adjustment for age and BMI. The C allele frequency increased the risk of disease by three and half times when compared with those of T allele (OR= 3.49, 95 % C. I= 2.6-4.67, P < 0.0001). Conclusion: We conclude from this study that the gene polymorphism of VDR-FOKI was associated with high risk of development and progression of breast cancer.
Keywords: breast cancer, VDR-FOKI, gene, polymorphism, females, Iraq
Edition: Volume 9 Issue 7, July 2020
Pages: 1081 - 1086
Make Sure to Disable the Pop-Up Blocker of Web Browser
Similar Articles
Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Masters Thesis, Biomedical Sciences, India, Volume 11 Issue 6, June 2022
Pages: 1769 - 1772Semi - Automatic Segmentation of Human Breast from Thermal Images for Analysis of Human Breast Cancer
A. R. Shwethaa, Divyashree .K
Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Biomedical Sciences, Indonesia, Volume 12 Issue 6, June 2023
Pages: 2044 - 2049Phytochemical Analysis, Antioxidant Activity, and Cytotoxic Activity of Lentinula Edodes (Shiitake Mushroom) Extracts towards Breast Cancer Cell Line T47D
Ade Arsianti
Downloads: 97
Research Paper, Biomedical Sciences, Iraq, Volume 6 Issue 10, October 2017
Pages: 1238 - 1242Incidence Rate of Infectious Diseases in Hospitalized Children
Maysaa Kadhim Al-Malkey, Istabraq A. Beram, Alyaa W. Saadi
Downloads: 102
Review Papers, Biomedical Sciences, India, Volume 6 Issue 5, May 2017
Pages: 1683 - 1684Microbiome and Cancer
Nivaasini Sivarajah
Downloads: 127 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Biomedical Sciences, Indonesia, Volume 6 Issue 4, April 2017
Pages: 654 - 658The Correlation between Mammaglobin a mRNA Concentration in Peripheral Blood and Clinical Stages of Breast Cancer Patients at Sanglah General Hospital
Suryawisesa I.B.M., Setiawan I.G.B, Widiana I.K, Sudarsa IW, Manuaba I.B.T.W, Gusti NK Mahardika, Utami I.G.A.A.J.W.