A Comparative Evaluation of Dexmedetomidine versus Midazolam-fentanyl for Sedation in Vitreoretinal Surgery under Peribulbar Anaesthesia
Abstract: Introduction: Midazolam fentanyl (MDZ: FEN) combination is frequently used for intravenous sedation in ophthalmic surgeries in adults. Dexmedetomidine (DEX), is also indicated for procedural sedation. However, it may cause deeper sedation and patient non-coperation at recommended doses. Aims and objectives: To evaluate the efficacy and safety of low dose of i. v. dexmedetomidine (DEX) (0.25 microgm/kg) versus i. v midazolam-fentanyl (MDZ: FEN) (0.5mg/25microgm) for vitreoretinal surgeries under peribular anesthesia in adults. Materials and methods: In a randomized, double-blind, interventional study, 60 patients (30 each group) aged 20-60 years, scheduled for vitreoretinal surgery under peribulbar block were divided equally to receive either iv MDZ: FEN (0.5mg/25microgm) or iv DEX (0.25 microgm/kg) dose over 10 mins. The vital parameters, ramsay sedation score (RSS), surgeon satisfaction score & effect on respiration were noted. Results: The ‘DEX’ group patients had stable haemodynamics, level 3 sedation and surgeon satisfaction score of 2–3 (good to excellent operating conditions) with no respiratory depression. The sedation score (RSS) of 3 was achieved at approx 5.3 minutes in MDZ: FEN group as compared to 11.5 minutes in DEX group (p
Keywords: vitreoretinal, ophthalmic, dexmedetomidine, peribulbar-block, monitored anaesthesia care MAC
How to Cite?: Dr. Ramakant Sharma, Dr. Alaka Purohit, "A Comparative Evaluation of Dexmedetomidine versus Midazolam-fentanyl for Sedation in Vitreoretinal Surgery under Peribulbar Anaesthesia", Volume 9 Issue 5, May 2020, International Journal of Science and Research (IJSR), Pages: 1615-1621, https://www.ijsr.net/getabstract.php?paperid=SR20526180317, DOI: https://dx.doi.org/10.21275/SR20526180317