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Research Paper | Medical Surgical | India | Volume 9 Issue 3, March 2020
Efficacy of a Timely Amniotic Membrane Grafting in a Case of Steven Johnson Syndrome
Gayatri Bhonsale | Ishita Mehta | Mamta Agrawal [2] | Suvarna Kalapad [2]
Abstract: Steven Johnson Syndrome, A fatal drug reaction which though rare, has a high morbidity and mortality.48yr male came with sudden onset redness & pain in eyes, fever and rashes on legs & ulceration in oral cavity (developed over few hours) with a 3 day history of intake of Norfloxacin & Carbamazepine for fever and UTI. Systemically- hyperpyrexia, target lesions over lower limb, & ulcerative tender lesions on lips, oral mucosa, tongue & palate. Ocular examination – VA 6/6, lid oedema with ulceration, congestion & extensive forniceal pseudomembranes & a clear cornea. Was diagnosed as SJS and started on iv antibiotics, topical lubricants, steroids & antibiotics. Both eyes underwent AMG within the 1st week with good outcome at 4wk followup. SJS is an acute inflammatory polymorphic disease affecting skin, mucous membranes & eye. Ophthalmic involvement ranges from mild mucopurulent conjunctivitis to severe perforating corneal ulcers in 50 % of patients. If untreated in a timely fashion, morbidity occurs with late corneal complications - opacities, vascularization, perforation & ocular surface abnormalities like symblepharon, occasionally leading to blindness. With early presentation and prompt treatment these dreaded complications were prevented & good results achieved.
Keywords: Steven Johnson Syndrome, Amniotic Membrane Grafting AMG
Edition: Volume 9 Issue 3, March 2020,
Pages: 1450 - 1453