Efficacy of a Timely Amniotic Membrane Grafting in a Case of Steven Johnson Syndrome

Gayatri Bhonsale, Ishita Mehta, Mamta Agrawal, Suvarna Kalapad

Abstract: Steven Johnson Syndrome, A fatal drug reaction which though rare, has a high morbidity and mortality.48yr male came with sudden onset redness & pain in eyes, fever and rashes on legs & ulceration in oral cavity (developed over few hours) with a 3 day history of intake of Norfloxacin & Carbamazepine for fever and UTI. Systemically- hyperpyrexia, target lesions over lower limb, & ulcerative tender lesions on lips, oral mucosa, tongue & palate. Ocular examination – VA 6/6, lid oedema with ulceration, congestion & extensive forniceal pseudomembranes & a clear cornea. Was diagnosed as SJS and started on iv antibiotics, topical lubricants, steroids & antibiotics. Both eyes underwent AMG within the 1st week with good outcome at 4wk followup. SJS is an acute inflammatory polymorphic disease affecting skin, mucous membranes & eye. Ophthalmic involvement ranges from mild mucopurulent conjunctivitis to severe perforating corneal ulcers in 50 % of patients. If untreated in a timely fashion, morbidity occurs with late corneal complications - opacities, vascularization, perforation & ocular surface abnormalities like symblepharon, occasionally leading to blindness. With early presentation and prompt treatment these dreaded complications were prevented & good results achieved.

Keywords: Steven Johnson Syndrome, Amniotic Membrane Grafting AMG

How to Cite?: Gayatri Bhonsale, Ishita Mehta, Mamta Agrawal, Suvarna Kalapad, "Efficacy of a Timely Amniotic Membrane Grafting in a Case of Steven Johnson Syndrome", Volume 9 Issue 3, March 2020, International Journal of Science and Research (IJSR), Pages: 1450-1453, https://www.ijsr.net/getabstract.php?paperid=SR20318183205, DOI: https://dx.doi.org/10.21275/SR20318183205