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Research Paper | Medical Science | India | Volume 9 Issue 11, November 2020
To Evaluate the Significance of Hyperhomocysteinemia in Patients with Coronary Artery Disease
Dr. Pritish Ingole | Dr Tukaram Aute  | Dr. Ashish Deshpande
Abstract: Coronary artery disease (CAD) is considered to be the most common cause of mortality worldwide from the last some years (from 1990s). Homocysteine is described as the promoter for atherosclerotic disorder in the middle aged. Here in this study we are going to evaluate the relationship between levels of serum homocysteine with coronary artery disease. It has been shown that fasting serum homocysteine levels in CAD patients were higher than the patients without coronary artery disease. Whereas the rise of Homocysteine levels in a patient with coronary artery disease, increases the severity of CAD. This is the reason behind the implication of homocysteine as a novel risk factor for Coronary artery disease in the entire world. Though many studies in this regard failed to demonstrate the direct correlation between CAD and homocysteine levels. In the general prospective population of aged men, it is considered that high homocysteine level is common and strongly associated with coronary heart disease and coronary artery disease yet its contribution in young patients is uncertain. Although some studies have revealed that vitamin B12 is the major cause of increased homocysteine but vitamin supplementation can be used to decrease the level of homocysteine and prevent the patient from CAD risk. As a whole and according to all the data, it suggests that homocysteine is not a cause of CAD but it can be considered as a marker which leads to the risk of it. Therefore to prevent the threat all the necessary precautions need to be taken by the patient and a proper medical check up is also mandatory. Following the medical guidelines any patient can get rid of from the risk of CAD by proper diet and by decreasing the homocysteine level.
Keywords: Hyperhomocysteinemia, coronary artery disease CAD, Homocysteine, Endothelial dysfunction, folic acid
Edition: Volume 9 Issue 11, November 2020,
Pages: 1298 - 1309