International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 66 | Views: 249

Research Paper | Microbiology | India | Volume 9 Issue 11, November 2020 | Popularity: 6.7 / 10


     

Role of CBNAAT for Early Diagnosis of Pulmonary Tuberculosis and Percentage of Rifampicin Resistance among the Patients Admitted in Government General Hospital, Siddipet

Dr. Taruni, Dr. S. L. Annapoorna


Abstract: India is the highest tuberculosis (TB) burden country in the world. The global incidence of multidrug-resistant TB (MDR-TB) is 630, 000 cases. India constitutes one tenth of the global burden with 64, 000 cases, presently. Though the conventional drug susceptibility testing (DST) is con standard for the detection of drug-resistant TB, it is time-consuming taking about 6–8 weeks. Hence, there is need of introduction of rapid diagnostic tools to detect MDR-TB. Cartridge-based nucleic1. Aims and objective of the study: To assess diagnostic usefulness of Gene Xpert MTB/RIF assay technique in comparision with routine smear microscopy, so that early detection is essential to reduce the death rate and interrupt transmission and detection of percentage of rifampicin resistance among the positive samples, it helps to avoid injudicious use of anti tubercular drugs. Material and methods: This is a retrospective study conducted in the department of Microbiology, Government General hospital, Siddipet, between january 2018 to december 2018. Early morning sputum sample was collected from the patients in a clean sterile container. Results: Among the total 2129 samples, 474 were detected tuberculosis positive by CBNAAT method and 1568 were negative. And among 474 positive cases, 439 were Rifampicin sensitive and 35 were Rifampicin resistant. Conclusion: CBNAAT detects pulmonary TB with greater efficacy than sputum microscopy also helping in early diagnosis in less than 2 hours. It also detects rifampicin resistance with high specificity and can be used for screening for MDR-TB so that early therapy can be started thus decreasing the incidence of MDR-TB. WHO recommends CBNAAT for early diagnosis of pulmonary tuberculosis and detection of rifampicin resistance and retreatment cases, who are at risk of MDR-TB.


Keywords: CBNAAT Catridge-based nucleic acid amplification test, MDR Multi drug resistance, Pulmonary tuberculosis, Gene Xpert, Rifamipicin


Edition: Volume 9 Issue 11, November 2020


Pages: 1276 - 1279



Make Sure to Disable the Pop-Up Blocker of Web Browser




Text copied to Clipboard!
Dr. Taruni, Dr. S. L. Annapoorna, "Role of CBNAAT for Early Diagnosis of Pulmonary Tuberculosis and Percentage of Rifampicin Resistance among the Patients Admitted in Government General Hospital, Siddipet", International Journal of Science and Research (IJSR), Volume 9 Issue 11, November 2020, pp. 1276-1279, https://www.ijsr.net/getabstract.php?paperid=SR201121200147, DOI: https://www.doi.org/10.21275/SR201121200147



Similar Articles

Downloads: 2 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Dissertation Chapters, Microbiology, India, Volume 13 Issue 2, February 2024

Pages: 1241 - 1244

Utility of Oral Swab in the Diagnosis of Pulmonary Tuberculosis

Garima Kalla, Swapana Kanade, Gita Nataraj

Share this Article

Downloads: 3

Research Paper, Microbiology, Libya, Volume 10 Issue 12, December 2021

Pages: 330 - 336

Influencing Factors on Mycobacterium tuberculosis that Causes Tuberculosis (TB) in Benghazi: Environmental and Behavioral Factors

Latifa Abdel-Hafid Jwieli, Heba Gweili El Majbri, Hameda Ali Mohamed Naser El-Moghrabi, Nadia Ali Elramli, Hadir Gawili, Faitor Abdel-Malek Faitor

Share this Article

Downloads: 3 | Weekly Hits: ⮙3 | Monthly Hits: ⮙3

Case Studies, Microbiology, India, Volume 12 Issue 7, July 2023

Pages: 1196 - 1201

Prevalence of Pulmonary Tuberculosis among Different Age Groups and Sex

Aysha Salim

Share this Article

Downloads: 4 | Weekly Hits: ⮙2 | Monthly Hits: ⮙2

Research Paper, Microbiology, India, Volume 13 Issue 5, May 2024

Pages: 69 - 72

Detection of Rifampicin Resistance in Pulmonary Tuberculosis by Molecular Methods in a Tertiary Care Hospital

Dr. I. Divya Sri, Dr. N. Padma Priya, Dr. Sireesha Chava, Dr. Sulakshana Sony Cheemala

Share this Article

Downloads: 128

Research Paper, Microbiology, India, Volume 5 Issue 2, February 2016

Pages: 785 - 788

Early Detection of Drug Susceptibility Test for Mycobacterium Tuberculosis by Slide DST Method Using Two Media- Middle Brook 7H9 Broth and Human Blood Media

Amruta Patil, Dr. P. B. Desai

Share this Article
Top