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Research Paper | Biochemistry | Volume 3 Issue 10, October 2014 | Pages: 508 - 514 | Nigeria
Association of Brain-Derived Neurotrophic Factor (BDNF) Variant (rs6265) with Overweight/Obesity orOverfatness, and Effect of Physical Activity Levels in Adolescents Population
Abstract: Childhood and adolescents obesity are worldwide health issue, characterized by various somatic, psychosocial and psychiatric complications, which translates to adult obesity and other related complications. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that mediates feeding habit, food intake, energy metabolism and weight control. A common variant of the BDNF gene (rs6265) has been associated with various forms of eating disorders, influencing body mass index (BMI) and obesity in various populations. Yet, no similar finding was reported on Malaysian adolescents population to date. The aim of this study was to determine the association between this variant and obesity, and to ascertain the influence of physical activity levels on the variant in 564 Malaysian adolescents of different ethnic background. We genotyped the variant using TaqMan-based allele-specific PCR assay and the result was analysed using SPSS statistical analysis software, in line with levels of physical activity recorded earlier on. Comparison between overweight/obese and lean individuals revealed that rs6265 A risk allele which is also theminor allele was significantly associated with risk for overweight/obese (p
Keywords: body fat percentage BF %, body mass index BMI, brain-derived neutrophin factor BDNF, Obesity, Physical activity and variant
How to Cite?: Jaafaru Sani Mohammed, Muthu Kumar Veerapen, Zoe Yi Ng, Renee Lim Lay Hong, "Association of Brain-Derived Neurotrophic Factor (BDNF) Variant (rs6265) with Overweight/Obesity orOverfatness, and Effect of Physical Activity Levels in Adolescents Population", Volume 3 Issue 10, October 2014, International Journal of Science and Research (IJSR), Pages: 508-514, https://www.ijsr.net/getabstract.php?paperid=SEP1484, DOI: https://dx.doi.org/10.21275/SEP1484