The HELLP Syndrome: Clinical Issues and Complications. Management and Two Different Profilatic Considerations and Treatments: Heparin vs Dexamethason: A Review

Prof. A. Manaj, E. Bylykbashi, M. Muhametaj M. D., I. V. Bylykbashi

Abstract: Background HELLP, a syndrome characterized by Hemolysis, Elevated Liver enzyme levels and a Low Platelet count, is an obstetric complication that is frequently misdiagnosed at initial presentation. Many investigators consider the syndrome to be a variant of preeclampsia, but it may be a separate entity. The pathogenesis of HELLP syndrome remains unclear. Early diagnosis is critical because the morbidity and mortality rates associated with the syndrome have been reported to be as high as 25 percent. Its incidence is reported as 0.2-0.6% of all pregnancies. Of women with preeclampsia, 4-12% also develop signs of a superimposed HELLP syndrome, mortality is 7-35% and perinatal mortality of the child may be up to 40%. . Though delivery is the ultimate therapeutic option, medical treatments, including the use of heparin or corticosteroids, have been employed in the attempt to improve maternal prognosis. OBJECTIVE: The aim of this retrospective study during 2004-2013, in our hospital, was to detect incidence and the risk factors and to compare the time course of recovery and the incidence of complications in women with HELLP syndrome receiving either heparin or dexamethasone. METHODS:. Between January 2004 and December 2013, 32 patients with HELLP syndrome were cared for at the Institute of Obstetrics and Gynecology of the University of Tirana: 20 patients were treated with heparin, administered subcutaneously at a dose of 5000 IU every 12 h, whereas 12 women received dexamethasone, administered intravenously at a dose of 10 mg every 12 h. Categorical data were evaluated with chi-square and Fisher's exact test; continuous data were analyzed with Mann? Whitney U test; P

Keywords: HELLP syndrome, Preeclampsia, Eclampsia, Heparin, Dexamethasone

How to Cite?: Prof. A. Manaj, E. Bylykbashi, M. Muhametaj M. D., I. V. Bylykbashi, "The HELLP Syndrome: Clinical Issues and Complications. Management and Two Different Profilatic Considerations and Treatments: Heparin vs Dexamethason: A Review", Volume 3 Issue 10, October 2014, International Journal of Science and Research (IJSR), Pages: 1580-1584, https://www.ijsr.net/getabstract.php?paperid=SEP14661, DOI: https://dx.doi.org/10.21275/SEP14661

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