International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 118 | Views: 303 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Pathology | India | Volume 3 Issue 10, October 2014 | Popularity: 6.9 / 10


     

Predictive Value of Micronucleus Count in Cervical Smears of Normal, Infective Inflammatory & Intraepithelial Neoplasia Pathology in Perimenopausal Women

Jeevaraj Giridharan, Uma.A.Natarajan, Dhananjay.S Kotasthane


Abstract: Objectives: Consenses guidelines establish that a micronucleus is a small additional nucleus formed due to chromosomal loss or fragmentation. Its a good prognostic indicator for monitoring genetic damage in human population. The objective of this study was to get the predictive value of micronucleus count in cervical smears of normal, infective inflammatory and intraepithelial neoplasia pathology in perimenopausal women and to prove Micronucleus evaluation in routine Pap smears is a very useful biomarker in cervical cancer screening. Material and Method: In this study 90 cases, consisting of 30 normal, 30 trichomonas infective, 30 intraepithelial neoplasia cervical smears of perimenopausal women of age group of (40-45) 2 years in Mahatma Gandhi Medical College and Research Institute, Puducherry from January 2014 - June 2014 were studied for micronucleus count. Only routine papanicolaou-stained cervical smears were used. In each smear, the number of micronucleated cells were counted under high power and expressed as a count per 1, 000 cells. Observation & Results: The predictive value of micronucleus count in squamous intraepithelial lesion > infective inflammatory cervical > normal cases. The p value is < 0.01, that is significant. Conclusions: This simple micronucleus test is a powerful biomarker and can be used as a screening procedure in predicting cervical cancer.


Keywords: Micronucleus, Cervical smears, Perimenopausal women, Cervical neoplasia


Edition: Volume 3 Issue 10, October 2014


Pages: 1571 - 1574



Make Sure to Disable the Pop-Up Blocker of Web Browser




Text copied to Clipboard!
Jeevaraj Giridharan, Uma.A.Natarajan, Dhananjay.S Kotasthane, "Predictive Value of Micronucleus Count in Cervical Smears of Normal, Infective Inflammatory & Intraepithelial Neoplasia Pathology in Perimenopausal Women", International Journal of Science and Research (IJSR), Volume 3 Issue 10, October 2014, pp. 1571-1574, https://www.ijsr.net/getabstract.php?paperid=OCT14559

Similar Articles

Downloads: 136

Research Paper, Pathology, Indonesia, Volume 5 Issue 2, February 2016

Pages: 510 - 514

Analyze the Expression of Cytokeratin 5 on the Epithelial Cells of the Buccal Mucosa in Batik Workers

Juni Handajani, Dhinintya Hyta Narissi

Share this Article

Downloads: 2

Research Paper, Pathology, India, Volume 11 Issue 3, March 2022

Pages: 1360 - 1364

Micronuclear Assay in Breast Aspirate Smears and its Diagnostic Utility in Borderline Cases

Vudata Ramya Swathi, Adimulam Hareesh Kumar, M Janaki

Share this Article

Downloads: 144

Research Paper, Pathology, India, Volume 8 Issue 3, March 2019

Pages: 805 - 809

Cytomorphological Study of Cervical Smear and Its Correlation with Socio-Economic Status

Dr Shubhangi Kachore, Dr Pragati Karmarkar, Dr Chaitanya R Patil

Share this Article
Top