International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 111 | Views: 197

Research Paper | Medicine Science | India | Volume 3 Issue 10, October 2014


Regulatory Role of Doxycycline on Expression of mi-RNA in Tumorigenesis Pathway of Colorectal Cancer

Neha Nanda | Devinder Kumar Dhawan | Safrun Mahmood


Abstract: Downregulation of mir-143 and mir-145 has been demonstrated as a common feature of colon cancer. Several studies have shown that upregulation of mir-143 and mir-145 may be a good aspect for therapeutic purposes in the treatment of colon cancer. Doxycycline an anti-tumorigenic agent, was studied to determine the modulation of mir-143 and mir-145 expression in DMH-induced colon cancer in rats. We have found that doxycycline (DMH/DOX) unexpectedly increased aberrant crypt foci (ACFs) in DMH treated rats and caused progression of colonic tumor growth. Further analysis of mir-143 and mir-145 expression in control and treated rats, showed that compared to controls the expression of mir-143 and mir-145 was diminished in DMH/DOX treated rats. The data suggest that Doxycycline enhances tumorous growth in colon of DMH treated rats and does not modulate the expression of mir-143 and mir-145 in colon cancer.


Keywords: Doxycycline, mir-143, mir-145, ACFs, Colon cancer


Edition: Volume 3 Issue 10, October 2014,


Pages: 1377 - 1380


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