Study of Serum High-Sensitivity C-Reactive Protein, Ferritin and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus

Dr. Sushma B Jagannatha, Dr. Shrikant Chandrakar

Abstract: Introduction Systemic inflammatory activity plays a key role in the pathogenesis and progression of atherosclerosis in subjects with type 2 diabetes. Hence evaluation of inflammatory novel biomarkers like high-sensitivity C-reactive protein and ferritin serves as tools for cardiovascular risk prediction. Objectives to evaluate the levels of high-sensitivity C-reactive protein (hs-CRP), ferritin & glycated haemoglobin in controls and type 2 diabetic subjects and to assess the correlations if any, between fasting serum glucose, hs-CRP, ferritin & glycated haemoglobin. Materials and Methods A total number of 100 subjects were studied, comprising of 50 controls and 50 type 2 diabetic subjects. Diabetic subjects were further divided depending upon treatment modalities. Serum levels of hs-CRP, ferritin were measured by Chemiluminescense Immunoassay. Glycated haemoglobin was measured by Nephelometry. The statistical analysis was carried out using studentt test and Karl Pearsons coefficient of correlation. Results hs-CRP, ferritin & glycated haemoglobin levels were found to be significantly increased (p<0.01) in type 2 diabetic subjects compared to controls. There was highly significant (P<0.01) positive correlations existed between fasting serum glucose, hs-CRP and HbA1c. Discussion & Conclusion Elevated levels of hs-CRP and ferritin predict the future cardiovascular complications in type 2 diabetic subjects. Glycated haemoglobin serves as a simple and rapid biomarker to assess glycemic control in type 2 diabetic subjects. The current study demonstrates that higher HbA1c levels are significantly associated with elevation of hs-CRP. These results imply a significant relation between glycemic control, inflammation and cardiovascular risk. Type 2 Diabetes Mellitus, Glycated haemoglobin, High-sensitivity C-reactive protein & Ferritin

Keywords: Type 2 Diabetes Mellitus, Glycated haemoglobin, High-sensitivity C-reactive protein & Ferritin