Protective Effect of Garcinia kola Seed and Honey Mixture against Cadmium-Induced Hepatotoxicity in Wistar Albino Rats
Abstract: Traditional African herbs, plants and fluid have been reported to exhibit therapeutic, curative and protective effect against sicknesses, diseases and even poisonous agents. In this study, Garcinia kola seed (GKS), Honey or a mixture of both were investigated for protective action against Cadmium-induced Hepatotoxicity in wistar albino rats. Different groups of the animals were fed GKS (of different dose regimen of 50mg/100g body weight and 100mg/100g body weight), honey or a mixture of both (of dose concentration of 50mg/100g body weight) for 14 days and then co-administered orally with cadmium acetate from the 14h to 21st day. Liver cell injury was assessed by the determination of plasma total and conjugated Bilirubin, aspartate aminotransferase (AST), alanine amino transaminase (ALT) and gamma Glutamyl transferase (GGT). Histological studies on the Liver was done for 3 rats in each group using Haematoxylin and eosin stain (H and E stain), and their pictographs (x 400 magnification) was reported. Results obtained showed that administration of cadmium acetate alone caused a significant increase (p
Keywords: Garcinia kola Seed Aspartate transaminase Alanine transaminase Gamma Glutamyl transferase, Cadmium
How to Cite?: D. G. Tamuno-Emine, A. F. Anyia, "Protective Effect of Garcinia kola Seed and Honey Mixture against Cadmium-Induced Hepatotoxicity in Wistar Albino Rats", Volume 5 Issue 5, May 2016, International Journal of Science and Research (IJSR), Pages: 356-363, https://www.ijsr.net/getabstract.php?paperid=NOV163054, DOI: https://dx.doi.org/10.21275/NOV163054