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Research Paper | Chemistry | India | Volume 5 Issue 3, March 2016
RP-HPLC Method Development and Validation for the Analysis of Pharmaceutical Drugs ? Paracetamol
Abstract: A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of PARACETAMOL. Isocratic elution at a flow rate of 1.0 ml /min was employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of Acetonitrile 0.1M Acetic Acid 5050 (v/v). The UV detection wavelength was at 210 nm. Linearity was observed in concentration range of 100-140 mg/ml. The retention time for Paracetamol was 3.0 min. The method was validated as per the ICH guidelines. The proposed method can be successfully applied for the estimation of Paracetamol.
Keywords: Paracetamol, Method Development, Validation, 210nm
Edition: Volume 5 Issue 3, March 2016,
Pages: 2093 - 2095