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Research Paper | Physiology Science | Volume 5 Issue 2, February 2016 | Pages: 1624 - 1631 | Egypt
Bone Marrow-Derived Mesenchymal Stem cells Infusion Ameliorates Hyperglycemia, Dyslipidemia, Liver and Kidney Functions in Diabetic Rats
Abstract: Diabetes mellitus is associated with hyperglycemia, lipoprotein abnormalities and various organs dysfunctions. Stem cell therapy offers a great promise for the repair of injured tissues and organs. The aim of this study was to explore the effects of mesenchymal stem cell derived from bone marrow of albino rats on hyperglycemia, hypoinsulinemia, dyslipidemia and liver and kidney dysfunctions in STZ diabetic rats. Rat bone marrow mesenchymal stem cells (BM-MSCs) were isolated, cultured, characterized and finally injected intravenously (2 106, via tail vein) into STZ-induced diabetic rats. The other diabetic (STZ) rats received no treatment. The diabetic (STZ) rats showed significant (P
Keywords: Bone marrow, Mesenchymal stem cell, Streptozotocin, Diabetes, Dyslipidemia
How to Cite?: Farozia Mousa, Karolin Kamel Abdel-Aziz, Horeya Abdel Gawad, Salwa Soliman Mahmoud, Mahmoud Saeed Elgamel, "Bone Marrow-Derived Mesenchymal Stem cells Infusion Ameliorates Hyperglycemia, Dyslipidemia, Liver and Kidney Functions in Diabetic Rats", Volume 5 Issue 2, February 2016, International Journal of Science and Research (IJSR), Pages: 1624-1631, https://www.ijsr.net/getabstract.php?paperid=NOV161558, DOI: https://dx.doi.org/10.21275/NOV161558