Clinical Profile, Management, and Predictors of Mortality in Fournier's Gangrene: A Retrospective Study
Abstract: Fournier's Gangrene (FG) is a rapidly progressive polymicrobial necrotizing fasciitis of the perineal, perianal, and genital regions requiring immediate surgical intervention. This retrospective observational cohort study evaluated the clinical presentation, microbiological spectrum, management strategies, and predictors of mortality among 64 patients managed at an Indian tertiary care teaching hospital from January 2021 to December 2025. Data were analyzed using univariable screens and a prespecified parsimonious multivariable logistic regression model. The overall in-hospital mortality rate was 15.6% (10/64). Type 2 Diabetes Mellitus (56.3%) and chronic alcoholism (43.8%) were the primary comorbidities, with Escherichia coli isolated as the dominant pathogen (51.6%). Non-survivors demonstrated advanced physiological derangements at triage, including marked hyponatremia and severe metabolic acidosis. Multivariable analysis showed that a presentation delay exceeding 72 hours from symptom onset (Adjusted Odds Ratio [aOR]: 4.65, 95% Confidence Interval [CI]: 1.08-19.92; P = 0.039) and an admission Fournier's Gangrene Severity Index (FGSI) score >9 (aOR: 10.84, 95% CI: 2.05-57.18; P = 0.005) were independent predictors of mortality. Rapid risk stratification using the FGSI tool paired with immediate, aggressive surgical debridement remains critical to optimizing patient survival.
Keywords: Fournier's Gangrene, Necrotizing Fasciitis, FGSI Score, Surgical Debridement, Sepsis
How to Cite?: Dr. Divyansh Kesharwani, Dr. Varushi, Dr. Uddhav, Dr. Amit Katlana, "Clinical Profile, Management, and Predictors of Mortality in Fournier's Gangrene: A Retrospective Study", Volume 15 Issue 7, July 2026, International Journal of Science and Research (IJSR), Pages: 481-483, https://www.ijsr.net/getabstract.php?paperid=MR26706111122, DOI: https://dx.doi.org/10.21275/MR26706111122