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Original Research | Pathology | Volume 15 Issue 6, June 2026 | Pages: 867 - 872 | India
Study of Clinico-Hematological Profile in Various Hemoglobinopathies at a Tertiary Care Centre in Central India
Abstract: Background: Hemoglobinopathies are among the most common inherited hematological disorders worldwide and constitute a major public health problem in India. Their prevalence and clinical manifestations vary considerably across different geographical regions and ethnic populations. Aim: To evaluate the clinico-hematological profile of patients with various hemoglobinopathies and to assess their prevalence at a tertiary care centre in Central India. Materials and Methods: This observational, descriptive cross-sectional study included 100 patients with suspected or confirmed hemoglobinopathies attending a tertiary care centre in Central India over an 18-month period. Detailed demographic, clinical, and hematological data were collected. Complete blood counts, peripheral smear examination, and High-Performance Liquid Chromatography (HPLC) were performed for diagnosis and characterization of hemoglobinopathies. Results: Among the 100 patients studied, 54% were females and 46% were males. Sickle Cell Disease was the most common hemoglobinopathy, accounting for 69% of cases, followed by Sickle Cell Trait (10%), Thalassemia Trait (6%), HbS + Beta Thalassemia (6%), and Beta Thalassemia Minor (5%). The mean hemoglobin concentration was 8.59 g/dL, and the mean RBC count was 3.40 million/?L. HPLC analysis showed mean HbS, HbF, and HbA fractions of 56.14%, 13.68%, and 18.72%, respectively. Clinically, jaundice (70%), blood transfusion history (65%), joint pain (60%), and previous hospitalization (55%) were the most common findings. Conclusion: Sickle cell disorders constitute the predominant hemoglobinopathies in Central India and are associated with significant clinical morbidity and hematological abnormalities. HPLC remains an invaluable tool for accurate diagnosis and classification. Early detection, genetic counseling, and comprehensive management strategies are essential to reduce disease burden and improve patient outcomes.
Keywords: Hemoglobinopathies, Sickle Cell Disease, Thalassemia, HPLC, Hematological Profile, HbS, Central India, Anemia
How to Cite?: Dr Sathish V L, Dr Nitin Shende, Dr Balwant Kowe, "Study of Clinico-Hematological Profile in Various Hemoglobinopathies at a Tertiary Care Centre in Central India", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 867-872, https://www.ijsr.net/getabstract.php?paperid=MR26615143318, DOI: https://dx.dx.doi.org/10.21275/MR26615143318