Downloads: 1
Research Paper | Obstetrics and Gynecology | Volume 15 Issue 5, May 2026 | Pages: 734 - 737 | India
Study to Evaluate the Efficacy of the Test Detecting IGFBP-1 in the Diagnosis of Premature Rupture of Membranes
Abstract: Premature rupture of membranes is a common obstetric concern linked with infection, preterm birth, and fetal risk when diagnosis is delayed or uncertain. This cross-sectional study assessed the diagnostic accuracy of the Actim PROM test, based on insulin-like growth factor binding protein-1, among 60 pregnant women with watery vaginal discharge at BJ Medical College and Civil Hospital, Ahmedabad. Thirty women had clinically confirmed ruptured membranes, while 30 had intact membranes. Actim PROM showed 26 true positive, 29 true negative, 4 false negative, and 1 false positive result. The test showed 86.6% sensitivity, 96.6% specificity, 96.2% positive predictive value, 87.8% negative predictive value, and 91.6% overall accuracy. The results support Actim PROM as a rapid, simple, and useful non-invasive test for diagnosing PROM and guiding timely obstetric care.
Keywords: premature rupture of membranes, Actim PROM, IGFBP-1, pregnancy diagnosis, obstetric care
How to Cite?: Dr. Vidhi Thakkar, Dr. Shital Kapadia, Dr. Amiya Mehta, Dr. Hafsa Vohra, "Study to Evaluate the Efficacy of the Test Detecting IGFBP-1 in the Diagnosis of Premature Rupture of Membranes", Volume 15 Issue 5, May 2026, International Journal of Science and Research (IJSR), Pages: 734-737, https://www.ijsr.net/getabstract.php?paperid=MR26511151606, DOI: https://dx.dx.doi.org/10.21275/MR26511151606