Acute CNS Demyelinating Disorder Presenting with Optic Neuritis, Myelitis, and Seizures in a Young Female: A Diagnostic Challenge
Abstract: Acute demyelinating disorders of the central nervous system (CNS) can present with overlapping clinical and radiological features, making diagnosis challenging. We report a case of a 19-year-old female presenting with acute unilateral visual loss, seizures, and upper motor neuron signs. MRI revealed right retrobulbar optic neuritis and a cervical spinal cord lesion. Extensive infectious and autoimmune workup, including neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), was negative. The patient responded dramatically to corticosteroids and antiepileptics, with radiological and clinical improvement. This case highlights the importance of considering seronegative demyelinating disorders and early steroid therapy in atypical presentations.
Keywords: central nervous system demyelination, optic neuritis, spinal cord lesion, seronegative disorder, corticosteroid therapy
How to Cite?: Dr. Puratchi Kodi A, "Acute CNS Demyelinating Disorder Presenting with Optic Neuritis, Myelitis, and Seizures in a Young Female: A Diagnostic Challenge", Volume 15 Issue 4, April 2026, International Journal of Science and Research (IJSR), Pages: 26-27, https://www.ijsr.net/getabstract.php?paperid=MR26401112751, DOI: https://dx.doi.org/10.21275/MR26401112751