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Dissertation Chapters | Cardiology Science | Volume 15 Issue 2, February 2026 | Pages: 1148 - 1149 | India
Correlation of Serum 25-Hydroxy-Vitamin D Levels with Angiographic Severity of Coronary Artery Disease: A Case-Control Study Using Gensini Score
Abstract: Background: Vitamin D deficiency has been increasingly recognized as a potential cardiovascular risk factor. Its association with angiographic severity of coronary artery disease (CAD) remains under investigation. Objective: To evaluate the correlation between serum 25-hydroxy-vitamin D [25(OH)D] levels and angiographic severity of CAD assessed using the Gensini score. Methods: This hospital-based case-control, cross-sectional study was conducted at NRI Institute of Medical Sciences between June 2021 and November 2022. A total of 300 patients aged 30?70 years undergoing coronary angiography were enrolled. Patients with abnormal angiograms (n=150) were categorized as cases, and those with normal angiograms (n=150) served as controls. Serum 25(OH)D levels were measured and CAD severity was quantified using the Gensini scoring system. Statistical analysis included chi-square test, independent t-test, ANOVA, and Pearson correlation. Results: Mean serum vitamin D levels were significantly lower in cases compared to controls (23.4 ? 7.4 ng/mL vs 28.6 ? 6.3 ng/mL, p<0.001). Vitamin D levels progressively decreased with increasing vessel involvement (p<0.001). Mean Gensini score was significantly higher in cases (35.78 ? 49.66) compared to controls (1.06 ? 0.52, p<0.001). A strong negative correlation was observed between serum vitamin D levels and Gensini score (r = ?0.622, p<0.001). Conclusion: Vitamin D deficiency is significantly associated with both the presence and angiographic severity of CAD. Lower 25(OH)D levels correlate with higher Gensini scores and multivessel disease, suggesting a potential role of vitamin D in CAD pathophysiology.
Keywords: Vitamin D, 25(OH)D, Coronary artery disease, Gensini score, Angiographic severity
How to Cite?: Dr. Katari Subash, Dr. Ravitheja Vuyyuru, "Correlation of Serum 25-Hydroxy-Vitamin D Levels with Angiographic Severity of Coronary Artery Disease: A Case-Control Study Using Gensini Score", Volume 15 Issue 2, February 2026, International Journal of Science and Research (IJSR), Pages: 1148-1149, https://www.ijsr.net/getabstract.php?paperid=MR26216142552, DOI: https://dx.dx.doi.org/10.21275/MR26216142552