Study of Correlation of Mean Red Cell Volume and Red Cell Distribution Width with HbA1c and its Association with Microvascular Complications in Patients with Type 2 Diabetes Mellitus
Abstract: Background: Type 2 diabetes mellitus (T2DM) is a growing public health issue, with an estimated 537 million (10.5%) adults affected globally. In India, approximately 89.8 million adults (10.5% of the population) have diabetes. Chronic hyperglycemia in diabetes leads to microvascular complications (retinopathy, nephropathy, neuropathy), which are major causes of morbidity. Hematologic indices such as red blood cell distribution width (RDW) and mean corpuscular volume (MCV) have emerged as potential inflammatory markers and may reflect glycemic control. Objective: To evaluate the relationships of RDW and MCV with long-term glycemic control (HbA1c) and their associations with diabetic microvascular complications. Methods: In this cross-sectional study, 125 adults with established T2DM (on treatment) were enrolled (April 2023-June 2024). Exclusion criteria included type 1 diabetes, anemia (Hb2=4.38, p=0.036) and nephropathy (X2=3.96, p=0.047); e. g. patients with low MCV had only about half the odds of retinopathy compared to normal/high MCV (OR≈0.54). Normal-range RDW was significantly linked to a reduced likelihood of retinopathy (X2=7.12, p=0.008), although RDW was not significantly associated with neuropathy or nephropathy in this cohort. In multivariable analysis, poor glycemic control (HbA1c≥7%) markedly increased the odds of neuropathy (OR≈4.8, p
Keywords: type 2 diabetes mellitus, red blood cell indices, glycemic control markers, diabetic microvascular complications, routine blood parameters
How to Cite?: Dr. Jaydip Chabhadiya, Dr. Sundeep T Malhan, Dr. Hema Bojani, "Study of Correlation of Mean Red Cell Volume and Red Cell Distribution Width with HbA1c and its Association with Microvascular Complications in Patients with Type 2 Diabetes Mellitus", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 124-127, https://www.ijsr.net/getabstract.php?paperid=MR26101190211, DOI: https://dx.doi.org/10.21275/MR26101190211