A Study on Incidence of Minimal Hepatic Encephalopathy in Chronic Liver Disease Patients by Psychometric Methods

Arshiya Mubin S P, Sandeep Kumar Reddy G, Annareddy Tejeswara Reddy

Abstract: The quiet yet devastating effects of Minimal Hepatic Encephalopathy (MHE) have been long overlooked in the clinical management of cirrhotic patients. This study takes a closer, data-backed look at how MHE, though subtle in presentation, deeply affects cognitive functions such as attention, psychomotor speed, and visuo-spatial coordination. By using the Psychometric Hepatic Encephalopathy Score (PHES)-a straightforward paper-and-pencil battery of tests-researchers evaluated 100 cirrhotic patients and 100 healthy controls, drawing attention to the cognitive discrepancies that routine neurological exams often miss. What stands out here is the clear association between lower PHES scores (particularly below-6, as per Indian standardization), elevated MELD-Na values, and higher CTP classifications-especially Class C-indicating more severe liver dysfunction. Although factors like age, gender, etiology, or ascites didn?t significantly predict MHE, elevated SGPT levels and poor PHES performance were telltale signs. This suggests that the psychometric decline precedes visible clinical deterioration. It is evident that MHE is not just a precursor to overt hepatic encephalopathy, but a standalone concern that affects quality of life, work ability, and even road safety. What this study compellingly argues is not merely the prevalence of MHE-reported here at 28%-but the urgent need for its early detection using accessible tools like PHES, especially in resource-constrained settings. In sum, this isn?t just a clinical checklist-it?s a call to action to prioritize subtle cognitive health in liver disease care.

Keywords: Minimal hepatic encephalopathy, PHES testing, cirrhosis, cognitive impairment, liver disease screening

How to Cite?: Arshiya Mubin S P, Sandeep Kumar Reddy G, Annareddy Tejeswara Reddy, "A Study on Incidence of Minimal Hepatic Encephalopathy in Chronic Liver Disease Patients by Psychometric Methods", Volume 14 Issue 6, June 2025, International Journal of Science and Research (IJSR), Pages: 726-734, https://www.ijsr.net/getabstract.php?paperid=MR25610224555, DOI: https://dx.doi.org/10.21275/MR25610224555