Role of Post-ICD Intrapleural Streptokinase in Managing Loculated Pleural Effusion due to Pulmonary Tuberculosis: An Observational Study

Dr. Meghraj Jayantilal Chawada, Dr. Mahammad Ismail B Walikar, Dr. Sandeep Jadhav, Dr. Sumit Chavhan

Abstract: Loculated pleural effusion poses a significant challenge in pulmonary tuberculosis management, often necessitating adjunctive therapies to enhance drainage. This prospective observational study at Vilasrao Deshmukh Government Medical College, Maharashtra, evaluated the efficacy of post - intercostal drain (ICD) intrapleural streptokinase (STK) in 50 patients with loculated pleural effusion. Following ICD placement and STK administration, outcomes were assessed via fluid drainage volume, symptom relief, and radiological improvement, with statistical significance determined using an independent t - test (p<0.05). Results showed a marked increase in drainage, symptom resolution in most patients, and radiological improvement in 85% of cases, with no major complications. Post - ICD intrapleural STK appears to be a safe, effective intervention, warranting further large - scale studies to solidify its role in resource - limited settings.

Keywords: Loculated pleural effusion, intrapleural streptokinase, intercostal drain, fibrinolytic therapy, tuberculosis

How to Cite?: Dr. Meghraj Jayantilal Chawada, Dr. Mahammad Ismail B Walikar, Dr. Sandeep Jadhav, Dr. Sumit Chavhan, "Role of Post-ICD Intrapleural Streptokinase in Managing Loculated Pleural Effusion due to Pulmonary Tuberculosis: An Observational Study", Volume 14 Issue 3, March 2025, International Journal of Science and Research (IJSR), Pages: 1161-1167, https://www.ijsr.net/getabstract.php?paperid=MR25322223538, DOI: https://dx.doi.org/10.21275/MR25322223538